tag:blogger.com,1999:blog-26063966157975176512019-07-19T02:44:32.325-07:00Stem Cells FreakYour number one site for the latest stem cell newsStem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.comBlogger848125tag:blogger.com,1999:blog-2606396615797517651.post-57430261044034081072015-02-13T00:29:00.003-08:002015-02-13T00:29:51.257-08:00Observing Hematopoietic Stem Cells Differentiate Into Blood Cells in Living Mouse<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/-GzRlFwSjxjs/VN21AlKPoII/AAAAAAAACcg/RRILAqPLJhw/s1600/Dr.%2BHans-Reimer%2BRodewald.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://1.bp.blogspot.com/-GzRlFwSjxjs/VN21AlKPoII/AAAAAAAACcg/RRILAqPLJhw/s1600/Dr.%2BHans-Reimer%2BRodewald.jpg" height="200" width="175"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Dr. Hans-Reimer Rodewald<br>Credit: <a href="http://www.dkfz.de/en/zellimmunologie/" target="_blank">DKFZ</a></td></tr></tbody></table><b>German researchers develop a way to equip mouse hematopoietic (blood) stem cells with a fluorescent marker that can be switched on from the outside. Using this tool, they were able to observe, for the first time, how stem cells mature into blood cells under normal conditions in a living organism.</b><br><br>In the bone marrow, <a href="http://www.stemcellsfreak.com/p/hematopoietic-stem-cells.html" target="_blank">hematopoietic stem cells (HSCs)</a> give rise to a large variety of mature blood cells via progenitor cells at various stages of maturation. Now, scientists at the German Cancer Research Center (DKFZ) say have developed a way to equip mouse HSCs with a fluorescent marker that can be switched on from the outside.<br><br>Using this tool, they were able to observe, for the first time, how stem cells mature into blood cells under normal conditions in a living organism.<br><br>With these data, they developed a mathematical model of the dynamics of hematopoiesis. The researchers have now reported in the journal Nature that the normal process of blood formation differs from what scientists had previously assumed when using data from stem cell transplantations.<br></div><a href="http://www.stemcellsfreak.com/2015/02/observing-hematopoietic-stem-cells.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-54780382115952415292015-02-12T07:53:00.003-08:002015-02-12T07:53:48.001-08:00Hematopoietic Stem Cell Transplants Work Better than Drugs for Severe Multiple Sclerosis<div dir="ltr" style="text-align: left;" trbidi="on"><div><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://2.bp.blogspot.com/-OrMFfRPktec/VNzML8RmVYI/AAAAAAAACb8/-Qk1a_Whi0c/s1600/Multiple%2Bsclerosis%2Bdemyelination%2Bprocess.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://2.bp.blogspot.com/-OrMFfRPktec/VNzML8RmVYI/AAAAAAAACb8/-Qk1a_Whi0c/s1600/Multiple%2Bsclerosis%2Bdemyelination%2Bprocess.jpg" height="237" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Demyelination by multiple sclerosis. The CD68 colored tissue <br>shows several macrophages in the area of the lesion. <br>Original scale 1:100</td></tr></tbody></table><b>New study reveals that hematopoietic stem cell transplants may be more effective than the drug mitoxantrone for people with severe cases of multiple sclerosis.</b></div><div><br></div><div>The study appears in the online issue of Neurology®, the medical journal of the American Academy of Neurology.<br><br>A total of 21 people whose disability due to MS had increased during the previous year even though they were taking conventional medications (also known as first-line treatments) participated in the stydy. The participants, who had an average age of 36, were at an average disability level where a cane or crutch was required to walk.<br><br>Multiple sclerosis (MS) causes the body&#39;s immune system to attack its own central nervous system. In this phase II study, all of the participants received medications to suppress immune system activity.<br></div></div><a href="http://www.stemcellsfreak.com/2015/02/hematopoietic-stem-cell-transplants.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-42734964480742970842015-02-11T01:34:00.001-08:002015-02-11T01:34:29.383-08:00Global Stem Cells Announces Alliance with Regenerative Technology Alliance<div dir="ltr" style="text-align: left;" trbidi="on"><div><div class="separator" style="clear: both; text-align: center;"><a href="http://2.bp.blogspot.com/-dzBoVtTSe58/VNshgh3vUrI/AAAAAAAACbs/hptZwOSzjsw/s1600/global%2Bstem%2Bcells%2Bmemorandum.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="http://2.bp.blogspot.com/-dzBoVtTSe58/VNshgh3vUrI/AAAAAAAACbs/hptZwOSzjsw/s1600/global%2Bstem%2Bcells%2Bmemorandum.png"></a></div><div><b>Global Stem Cells Group announced yesterday that it has signed a memorandum of understanding with the Regenerative Technology Alliance (RTA) to evaluate and promote stem cell training programs.</b></div></div><div><br></div>Global Stem Cells Group and the Regenerative Technology Alliance (RTA) have signed a memorandum of understanding to evaluate and promote stem cell training programs.<br><div><br></div><div>RTA, a global provider of standards and certification for the emerging fields of regenerative medicine and science, will work along with the Global Stem Cells Group to evaluate the regenerative medicine company’s training programs and assess GSCG’s participating physicians against the RTA’s established international standards for the practice of regenerative and cell-based medicine.<br></div></div><a href="http://www.stemcellsfreak.com/2015/02/global-stem-cells-announces-alliance.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-67649523054124425242015-02-11T01:21:00.003-08:002015-02-11T01:21:50.880-08:00Engineers Put the 'Squeeze' on Human Mesenchymal Stem Cells<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://2.bp.blogspot.com/-XnGh98ZTl7s/VNseZalJaTI/AAAAAAAACbg/SxhYEs91HX0/s1600/Mesenchymal%2Bstem%2Bcell%2Btweezers.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://2.bp.blogspot.com/-XnGh98ZTl7s/VNseZalJaTI/AAAAAAAACbg/SxhYEs91HX0/s1600/Mesenchymal%2Bstem%2Bcell%2Btweezers.jpg" height="215" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Inside the cell, calcium ions are released from a structure called the <br>endoplasmic reticulum (ER). Forces applied to the bead cause ion channels <br>in the ER to open mechanically (shown in red above), rather through <br>biochemical signaling chemically (shown in green below). <br>Credit: Jie Sun/Peter Wang research group</td></tr></tbody></table><b>By using optical tweezers to squeeze a tiny bead attached to the outside of a human mesenchymal stem cell, scientists now know how mechanical forces can trigger a key signalling pathway in the cells. </b><br><b><br></b>This squeeze helps to release calcium ions stored inside the cells and opens up channels in the cell membrane that allow the ions to flow into the cells, according to Yingxiao Wang, leading author of the study and bioengineer at the University of California, San Diego.<br><br>It&#39;s long known that mechanical forces exerted on stem cells have a significant role to play in how the cells differentiate into other cells and form all kinds of tissues--like bone, skin and blood--from scratch. But until today, it hasn&#39;t been clear how some of these forces translate into the signals that prod the stem cells into building new tissue.<br></div><a href="http://www.stemcellsfreak.com/2015/02/engineers-put-squeeze-on-human.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-88761912384294336342015-02-10T08:39:00.000-08:002015-02-10T08:43:55.499-08:00Endothelial Cells Improve the Differentiation of Pluripotent Stem Cells to Blood Cells<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-iZTiE2_aX00/VNoyxDrzt9I/AAAAAAAACbA/EPqXSes9SCw/s1600/Hans-Peter%2BKiem.JPG" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://4.bp.blogspot.com/-iZTiE2_aX00/VNoyxDrzt9I/AAAAAAAACbA/EPqXSes9SCw/s1600/Hans-Peter%2BKiem.JPG"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Hans-Peter Kiem<br><a href="https://labs.fhcrc.org/kiem/Hans-Peter_Kiem.html" target="_blank">Credit</a></td></tr></tbody></table><div><b>Blood vessel cells improve the conversion of pluripotent stem cells like iPSCs to blood lineages.</b></div><div><br></div><div><a href="http://www.stemcellsfreak.com/p/hematopoietic-stem-cells.html" target="_blank">Hematopoietic stem cells</a> (HSCs) can differentiate into all the kinds of ce ls that comprise the blood and immune cell lineages. For decades now, hematopoietic stem cell transplantation is the only viable option for certain blood disorders, however, sources of HSCs are limited.<br><div><br></div><div>Pluripotent stem cells(PSCs), like <a href="http://www.stemcellsfreak.com/p/induced-pluripotent-stem-cells-ipscs.html" target="_blank">induced pluripotent stem cells</a> and <a href="http://www.stemcellsfreak.com/p/embryonic-stem-cells.html" target="_blank">embryonic stem cells</a> can differentiate into multiple types of cell lineages, but they do not readily reconstitute the population of cells in blood. </div><div><br></div><div>Now, a new study appearing Journal of Clinical Investigation reveals that the presence of endothelial cells, which make up the lining of blood vessels, improves the ability of PSC-derived cells to repopulate blood cell lineages.</div><div><br></div><div> Hans-Peter Kiem and his team at the Fred Hutchinson Cancer Research Center differentiated PSCs in the presence or absence of endothelial cells.<br></div></div></div><a href="http://www.stemcellsfreak.com/2015/02/endothelial-cells-improve.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-84679149624570544062015-02-06T11:39:00.002-08:002015-02-06T11:40:20.664-08:00Study Identifies Stem Cell Signaling Process That Gives Rise to Intestinal Tumors<div dir="ltr" style="text-align: left;" trbidi="on"><div><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/-Sf43bvLBj78/VNUX5_s8m1I/AAAAAAAACaA/iOjp5mxKfP4/s1600/intestinal%2Bcancer.png" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://1.bp.blogspot.com/-Sf43bvLBj78/VNUX5_s8m1I/AAAAAAAACaA/iOjp5mxKfP4/s1600/intestinal%2Bcancer.png"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Location and appearance of <br>two example intestinal tumors</td></tr></tbody></table><div><b>Researchers identify signaling molecules in intestinal stem cells that can give rise to cancer stem cells and tumors if left unregulated. The research suggests a new approach to targeting intestinal cancers.</b></div></div><div><br></div>Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) announced today that they have discovered a precise stem cell signaling process that can lead to intestinal tumors when disrupted.<br><div><br></div><div>Their findings add to our understanding of how stem cells give rise to tumors and identify specific stem cell molecules that may be targeted to prevent the onset, progression, and recurrence of intestinal cancers. The results of the study appear online in Cell Reports today.<br></div></div><a href="http://www.stemcellsfreak.com/2015/02/study-identifies-stem-cell-signaling.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-61749529279925339562015-02-06T00:16:00.000-08:002015-02-06T00:17:56.811-08:00Creative Medical Health Files Patent on Multiple Sclerosis Mesenchymal Stem Cell Therapy<div dir="ltr" style="text-align: left;" trbidi="on"><a href="http://3.bp.blogspot.com/-bRRQagAzlKA/VNR3etKO3CI/AAAAAAAACZw/yuD5ECXN_X0/s1600/creative%2Bmedical%2Bhealth%2Bmesenchymal%2Bstem%2Bcells.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="http://3.bp.blogspot.com/-bRRQagAzlKA/VNR3etKO3CI/AAAAAAAACZw/yuD5ECXN_X0/s1600/creative%2Bmedical%2Bhealth%2Bmesenchymal%2Bstem%2Bcells.png"></a>Creative Medical Health (CMH) announced today that it has filled a patent of intellectual property covering the utilization of its proprietary <a href="http://www.stemcellsfreak.com/p/mesenchymal-stem-cell.html" target="_blank">mesenchymal stem cell-based</a> product for treatment for autoimmune diseases, with multiple sclerosis being the first disease in which the product will be clinically assessed.<br><div><br></div><div>The patent covers various modifications and cell types that are used to specifically stop the immunological processes that cause inflammation in the nervous system, which leads to the pathology seen in multiple sclerosis.<br></div></div><a href="http://www.stemcellsfreak.com/2015/02/creative-medical-health-files-patent-on.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-61575910913359925852015-02-06T00:03:00.002-08:002015-02-06T00:03:47.159-08:00Human Embryonic Stem Cells Repair Brain Damage in Rats Caused by Radiation Therapy<div dir="ltr" style="text-align: left;" trbidi="on"><div><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/-bOamby5qAto/VNR0F4FIb3I/AAAAAAAACZg/_crm_jS_XX4/s1600/rats%2Btreated%2Bwith%2Bembryonic%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://1.bp.blogspot.com/-bOamby5qAto/VNR0F4FIb3I/AAAAAAAACZg/_crm_jS_XX4/s1600/rats%2Btreated%2Bwith%2Bembryonic%2Bstem%2Bcells.jpg" height="320" width="245"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Rats treated with the human cells regained cognitive <br>and motor functions that were lost after brain irradiation.<br>Credit: Dr. Denis Soulet, Laval University, Quebec</td></tr></tbody></table><div><b>Human stem cells used successfully to repair brain damage in rats caused by radiation therapy for cancer</b></div></div><div><br></div>For patients with brain cancer, radiation treatment is a powerful and potentially life-saving treatment, but it can also cause considerable and even permanent injury to the brain.<br><div><br></div><div>Now, through preclinical research conducted in rats, Memorial Sloan Kettering Cancer Center researchers have developed a new method to turn <a href="http://www.stemcellsfreak.com/p/embryonic-stem-cells.html" target="_blank">human embryonic stem cells</a> into cells that are instructed to repair damage in the brain. </div><div><br></div><div>Rats treated with the human cells regained cognitive and motor functions that were lost after brain irradiation. The study appeared in the February 5 issue of the journal Cell Stem Cell.<br><br>During radiation therapy for brain cancer, progenitor cells that later mature to produce the protective myelin coating around neurons are lost or significantly depleted, and there is no treatment available to restore them. These myelinating cells--called oligodendrocytes--are critical for shielding and repairing the brain&#39;s neurons throughout life.<br></div></div><a href="http://www.stemcellsfreak.com/2015/02/human-embryonic-stem-cells-repair-brain.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-32967603613145087832015-02-05T23:45:00.001-08:002015-02-05T23:48:20.019-08:00Malaria-in-a-Dish Paves the Way for Personalized Treatments<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://3.bp.blogspot.com/-aBDhD1-N-fc/VNRwYx-lFcI/AAAAAAAACY8/IhZprtQ7Ao0/s1600/Malaria%2Binduced%2Bpluripotent%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://3.bp.blogspot.com/-aBDhD1-N-fc/VNRwYx-lFcI/AAAAAAAACY8/IhZprtQ7Ao0/s1600/Malaria%2Binduced%2Bpluripotent%2Bstem%2Bcells.jpg" height="254" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Plasmodium vivax liver-stage infection in iPSC-derived <br>liver cells at eight days after infection. <br>Credit: Ng et al.</td></tr></tbody></table><b>MIT researchers use induced pluripotent stem cells, to screen potential antimalarial drugs and vaccines for their ability to treat the liver stage of malaria infection. </b><br><br>Researchers at the Massachusetts Institute of Technology (MIT) have engineered a way to use human liver cells, derived from <a href="http://www.stemcellsfreak.com/p/induced-pluripotent-stem-cells-ipscs.html">induced pluripotent stem cells</a>, to screen potential antimalarial drugs and vaccines for their ability to treat the liver stage of malaria infection. <br><br><div>This new approach may offer new opportunities for personalized antimalarial drug testing and the development of more effective individually tailored drugs to combat the disease, which causes more than 500,000 deaths worldwide each year. <br><br>The scientists presented their work in the February 5th issue of Stem Cell Reports, the official journal of the International Society for Stem Cell Research.<br><br><blockquote class="tr_bq"><i>&quot;Our platform can be used for testing candidate drugs that act against the parasite in the early liver stages, before it causes disease in the blood and spreads back to the mosquito vector. This is especially important given the increasing occurrence of drug-resistant strains of malaria in the field.&quot; </i>said senior study author Sangeeta Bhatia, MD, PhD, the director of MIT&#39;s Laboratory for Multiscale Regenerative Technologies and a biomedical engineer at Brigham and Women&#39;s Hospital.<br></blockquote></div></div><a href="http://www.stemcellsfreak.com/2015/02/malaria-in-dish-paves-way-for.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-47046867586960253312015-02-05T08:23:00.002-08:002015-02-05T08:23:22.040-08:00Results of Neural Stem Cells for Macular Degeneration to be Presented at Ophthalmology Conference<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://2.bp.blogspot.com/-6unJ2VyDc80/VNOXiCFl-uI/AAAAAAAACYk/OhWwyOrKOvo/s1600/Macular%2Bregeneration%2Btreatment%2Bwith%2Bneural%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://2.bp.blogspot.com/-6unJ2VyDc80/VNOXiCFl-uI/AAAAAAAACYk/OhWwyOrKOvo/s1600/Macular%2Bregeneration%2Btreatment%2Bwith%2Bneural%2Bstem%2Bcells.jpg" height="274" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Picture of the fundus showing intermediate <br>age-related macular degeneration</td></tr></tbody></table><div>StemCells, Inc. a company developing cell-based therapeutics for disorders of the central nervous system, announced today that it will present the results of its Phase I/II study in dry age related macular degeneration (AMD) at the Angiogenesis, Exudation and Degeneration 2015 symposium. </div><div><br></div><div>Specifically, it will be presenting the findings on the safety and preliinary efficacy of HuCNS-SC(R), <a href="http://www.stemcellsfreak.com/p/neural-stem-cells.html" target="_blank">human neural stem cells</a>, for AMD.</div><div><br></div><div>The presentation will be done by Theodore Leng, MD, MS, Clinical Assistant Professor of Ophthalmology at the Byers Eye Institute at Stanford, Stanford University School of Medicine and a principal investigator on StemCells, Inc.&#39;s study. Dr. Leng will present at 12:40 p.m. EST.<br></div></div><a href="http://www.stemcellsfreak.com/2015/02/results-of-neural-stem-cells-for.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-56820194252107962432015-02-04T23:14:00.001-08:002015-02-04T23:15:42.908-08:00Oklahoma Panel Passes Stem Cell Research Ban Bill<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-FgcJG6Mjrlc/VNMX4_gBHvI/AAAAAAAACYU/35cauruY044/s1600/human%2Bembryonc%2Bstem%2Bcells.JPG" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://4.bp.blogspot.com/-FgcJG6Mjrlc/VNMX4_gBHvI/AAAAAAAACYU/35cauruY044/s1600/human%2Bembryonc%2Bstem%2Bcells.JPG" height="240" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Human Embryonic Stem Cells</td></tr></tbody></table><b>A bill to to make embryonic stem cell research illegal and to further restrict abortion in Oklahoma both cleared a House committee on Wednesday, despite concerns from a doctor on the panel.</b><br><div><br>While activists gathered at the Capitol for the annual anti-abortion Rose Day rally, the House Public Health Committee voted mostly along party lines to approve both bills. An exception was Rep. Doug Cox, a Grove Republican and an emergency room physician who opposed both measures.<br><br>One bill would increase from 24 to 72 hours the amount of time a woman must wait before receiving an abortion after receiving certain information about the procedure, including the age of the fetus, risks involved and that ultrasound and heart tone monitoring are available.<br><br>Rep. Lisa Billy, R-Lindsay, said the purpose of the bill is to “empower women” by giving them more time to consider the implications of an abortion. But Cox said it amounted to government intrusion into a medical decision that should be between a woman and her doctor.<br><br>The other bill would make it a felony crime to perform <a href="http://www.stemcellsfreak.com/p/embryonic-stem-cells.html" target="_blank">embryonic stem cell research</a> in Oklahoma. The bill is opposed by many doctors and business groups like the Greater Oklahoma City Chamber of Commerce, who argue it could impede scientific research in Oklahoma.<br></div></div><a href="http://www.stemcellsfreak.com/2015/02/oklahoma-panel-passes-stem-cell.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-4528123532851321172015-02-04T23:02:00.003-08:002015-02-04T23:02:30.461-08:00Study Ties Three Genes to Radiation Resistance in Recurrent Tumors<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-3NSVyTCVHdg/VNMTVJGsE_I/AAAAAAAACX8/9xFC16XTQyU/s1600/glioblastoma.png" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://4.bp.blogspot.com/-3NSVyTCVHdg/VNMTVJGsE_I/AAAAAAAACX8/9xFC16XTQyU/s1600/glioblastoma.png" height="292" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Coronal MRI with contrast of a glioblastoma</td></tr></tbody></table><b>New research identifies three genes that together enable a lethal form of brain cancer to recur and progress after radiation therapy.</b><br><br>A new study has identified several genes that together enable a lethal form of brain cancer to recur and progress after radiation therapy.<br><br>The findings might lead to new therapies that target cancer stem cells, say researchers at The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James), who led the study. <br><div style="-webkit-text-stroke-width: 0px; background-color: white; color: #070809; float: right; font-family: Helvetica, Arial, sans-serif; font-size: 13px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: 15.6000003814697px; margin: 5px 0px 20px 20px; orphans: auto; text-align: left; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; width: 160px; word-spacing: 0px;"></div><br>The scientists focused on the brain cancer glioblastoma multiforme (GBM). They investigated a subset of cancer cells within those tumors that behave like stem cells and that sometimes survive radiation therapy. To understand how those cancer stem-like cells survive irradiation, the researchers examined the cancer-related gene EZH2, which is unregulated in GBM and other cancers.<br></div><a href="http://www.stemcellsfreak.com/2015/02/study-ties-three-genes-to-radiation.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-66666175818045215642015-02-04T07:42:00.002-08:002015-02-04T07:45:49.645-08:00Swedish Researchers Question Treatment of Infertility with Stem Cells<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-n40sNwz769k/VNI9R89vokI/AAAAAAAACXs/Ea5PquuNaow/s1600/Dr.%2BKui%2BLiu%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://4.bp.blogspot.com/-n40sNwz769k/VNI9R89vokI/AAAAAAAACXs/Ea5PquuNaow/s1600/Dr.%2BKui%2BLiu%2Bstem%2Bcells.jpg" height="233" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Dr. Kui Liu</td></tr></tbody></table><b>New research by Swedish scientists at the University of Gothenburg and Karolinska Institute questions the notion that infertility can be treated with stem cells.</b><br><br>Whether or not infertility can be treated with the help of stem cells has remained a debate for many years.<br><br>The classical theory is based on the idea that the eggs a woman has are the ones she has had from birth, but there are researchers who claim that stem cell research could lead to the creation of new eggs. If so, this would mean that infertile women, such as those who have entered the menopause, could be given new eggs.<br><br>New studies done by researchers at the University of Gothenburg and Karolinska Institute now show that the dream of successfully treating infertility with stem cells will probably not be realized. These new research studies have been published in the journal Proceedings of the National Academy of Sciences (PNAS).<br></div><a href="http://www.stemcellsfreak.com/2015/02/swedish-researchers-question-treatment.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-2555595824724607162015-02-04T07:33:00.001-08:002015-02-04T07:33:28.957-08:00ISCO Announces Completion of Cell Bank for Parkinson's Disease Clinical Trial<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-RtO6FO69eWo/VNI7RxteKyI/AAAAAAAACXg/nWUhcse-z58/s1600/human%2Bneural%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img alt="Human Neural Stem Cells turning into neurons" border="0" src="http://4.bp.blogspot.com/-RtO6FO69eWo/VNI7RxteKyI/AAAAAAAACXg/nWUhcse-z58/s1600/human%2Bneural%2Bstem%2Bcells.jpg" title="Human Neural Stem Cells"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Human Neural Stem Cells <br>Differentiating Into Neurons</td></tr></tbody></table><b>International Stem Cell Corporation (ISCO), a California-based biotechnology company developing stem cell-based therapies and biomedical products announced today that it has completed manufacturing of the cell bank of clinical-grade human neural stem cells using its patented process for the recently announced phase 1/2a clinical trial in Parkinson&#39;s disease. </b><br><div><br></div><div>The cell bank contains over 2.6 billion human cells, sufficient to meet the company&#39;s foreseeable clinical trial requirements.<br><br><blockquote class="tr_bq"><i>&quot;Completing the production of clinical-grade cells using the previously published protocol is one of the final steps before starting our clinical program. Because of the complexity involved in manufacturing live human cell products, having our own GMP facility is not only a strategic advantage, but also allows us to control the production costs. We continue to anticipate, subject to regulatory agency approval, beginning the clinical trial in early 2015 and will provide a further update in the near future.&quot;</i> said Ruslan Semechkin, Ph.D., ISCO&#39;s Chief Scientific Officer.<br></blockquote></div></div><a href="http://www.stemcellsfreak.com/2015/02/isco-announces-completion-of-cell-bank.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-53987784180836745872015-02-04T07:05:00.000-08:002015-02-04T07:05:11.601-08:00Brain Tissue Grown in 3-D Structure from Embryonic Stem Cells<div dir="ltr" style="text-align: left;" trbidi="on"><div><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://3.bp.blogspot.com/-0npiRAW6zwc/VNIzYFnSKYI/AAAAAAAACW0/jY_Vat1pzw8/s1600/tissue%2Bmade%2Bfrom%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://3.bp.blogspot.com/-0npiRAW6zwc/VNIzYFnSKYI/AAAAAAAACW0/jY_Vat1pzw8/s1600/tissue%2Bmade%2Bfrom%2Bstem%2Bcells.jpg" height="168" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">CALB and L7 are Purkinje-cell specific late markers are shown. <br>GRID2 is a marker for a Purkinje-specific glutamate receptor. <br>LHX5 is a marker for early Purkinje cells.<br>Credit: <a href="http://www.riken.jp/" target="_blank">Riken</a></td></tr></tbody></table><b>Researchers at the RIKEN Center for Developmental Biology in Japan recently announced that they have succeeded in inducing human embryonic stem cells to self-organize into a three-dimensional structure similar to the cerebellum, providing tantalizing clues in the quest to recreate neural structures in the laboratory. </b></div><div><br></div><div>One of the primary goals of stem-cell research is to be able to replace damaged body parts with tissues grown from undifferentiated stem cells. <br><br>For the nervous system, this is a particular challenge because not only do specific neurons need to be generated, but they must also be coaxed into connecting to each other in very specific ways.<br></div></div><a href="http://www.stemcellsfreak.com/2015/02/brain-tissue-grown-in-3-d-structure.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-18571563909307652032015-02-04T06:51:00.002-08:002015-02-04T07:18:23.963-08:00Immune Cells Could Prevent Bone Marrow Transplant Infections<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-SwuUlSzYMA8/VNIxUTJGHiI/AAAAAAAACWo/P2NqTxOTmIw/s1600/christopher%2Bsnyder.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://4.bp.blogspot.com/-SwuUlSzYMA8/VNIxUTJGHiI/AAAAAAAACWo/P2NqTxOTmIw/s1600/christopher%2Bsnyder.jpg" height="200" width="200"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Christopher Snyder<br><a href="http://www.jefferson.edu/university/jmc/departments/microbiology/faculty_staff/faculty/snyder.html" target="_blank">Credit</a></td></tr></tbody></table><b>Researchers discover clues for reducing infections after bone marrow transplantation for leukemia and lymphoma.</b><br><div><div><br>Bone marrow transplantation is a life-saving therapy for patients with blood cancers like leukemia or lymphoma. However, the depletion of the patient&#39;s immune system prior to transplantation can put patients at risk of for an infection by a virus called cytomegalovirus (CMV) that can be life threatening in these immune-compromised individuals. <br><br>Now, researchers at the Thomas Jefferson University say they have found that a very small subset of anti-viral immune cells, transplanted along with a donor&#39;s <a href="http://www.stemcellsfreak.com/p/adult-stem-cells.html" target="_blank">blood stem cells</a>, could be enough to fight and even prevent the disease caused by CMV, in research conducted in mice and published Jan 16th in the Journal of Immunology.<br></div></div></div><a href="http://www.stemcellsfreak.com/2015/02/immune-cells-could-prevent-bone-marrow.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-83663326703677483502015-02-03T12:27:00.000-08:002015-12-12T03:13:00.383-08:00Good Morning Snore Solution Mouth Appliance Review<div dir="ltr" style="text-align: left;" trbidi="on"><div class="separator" style="clear: both; text-align: center;"><a href="http://1.bp.blogspot.com/-EJIs8tP2nfQ/VNUeuV2HWEI/AAAAAAAAHh8/rJvif9wAl4s/s1600/good%2Bmorning%2Bsnore%2Bsolution.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="320" src="http://1.bp.blogspot.com/-EJIs8tP2nfQ/VNUeuV2HWEI/AAAAAAAAHh8/rJvif9wAl4s/s1600/good%2Bmorning%2Bsnore%2Bsolution.png" width="320"></a></div><b>Product Name:</b> Good Morning Snore Solution<br><b>Treats:</b> Snoring and mild to moderate apnea<br><b>Clinically Tested:</b> Good Morning Snore Solution is clinically tested and cleared by the Health Canada, FDA, EEA and ARTG<br><b>Money back guarantee:</b> Yes, GMSS comes with a full 30 day money back satisfaction guarantee<br><b>Price:</b> $99.94<br><b>Shipment:</b> Worldwide<br><b>Summary:</b> Good Morning Snore Solution is a clinically proven anti-snore mouthpiece that takes a unique and comfortable approach. Unlike awkward conventional jaw displacement devices it uses simple tongue displacement technology to cure your snoring.<br><b style="font-family: Georgia, Utopia, &#39;Palatino Linotype&#39;, Palatino, serif; font-size: 14px;">Rating:</b><span style="font-family: &quot;georgia&quot; , &quot;utopia&quot; , &quot;palatino linotype&quot; , &quot;palatino&quot; , serif; font-size: 14px;"> </span><span style="color: #b45f06; font-family: &quot;georgia&quot; , &quot;utopia&quot; , &quot;palatino linotype&quot; , &quot;palatino&quot; , serif; font-size: 14px;">★ ★ ★ ★ ★ </span><span style="font-family: &quot;georgia&quot; , &quot;utopia&quot; , &quot;palatino linotype&quot; , &quot;palatino&quot; , serif; font-size: 14px;">(5/5)</span><br><b>Order:</b> <a href="http://goo.gl/aETEiz" rel="nofollow" target="_blank"><b>Click here to order</b></a><br></div><a href="http://www.stemcellsfreak.com/2015/02/good-morning-snore-solution-review.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-5609903362695276012015-01-22T06:46:00.002-08:002015-01-22T07:18:31.950-08:00What Is the Cost of Cartistem?<div dir="ltr" style="text-align: left;" trbidi="on">You are probably reading these lines because you are interested in learning the costs of having the cartistem stem cell treatment. Unfortunately, giving an exact price is difficult as it depends on many factors, like the severity of your arthritis, how many knees you are getting done etc.<br><br><div>In general, cartistem is a relatively expensive treatment that is yet not covered by insurance companies. Expect to pay somewhere in the $20,000* range for the standard treatment and an additional $10,000 for every extra treatment. This price is only for one knee and doesn&#39;t include hospital stay (~1 week), airplane tickets, food expenses and anything else that might come up. Please note that the cartistem procedure is for now available exclusively in South Korea.<br></div></div><a href="http://www.stemcellsfreak.com/2015/01/cartistem-price.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-8595781471454415022014-08-18T04:01:00.000-07:002014-08-18T04:01:02.228-07:00Stem Cells Show How Illness-Linked Genetic Variation Affects Neurons<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://3.bp.blogspot.com/-zuvc_T8Enxw/U_Hb7FM4vfI/AAAAAAAACUk/xqLJcMZufhQ/s1600/cell%2Bnuclei%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://3.bp.blogspot.com/-zuvc_T8Enxw/U_Hb7FM4vfI/AAAAAAAACUk/xqLJcMZufhQ/s1600/cell%2Bnuclei%2Bstem%2Bcells.jpg" height="240" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">In this image, cell nuclei are shown in <br>blue and synapses in red and green.<br>Credit: Zhexing Wen/Johns Hopkins Medicine</td></tr></tbody></table>A genetic variation linked to schizophrenia, bipolar disorder and severe depression wreaks havoc on connections among neurons in the developing brain, a team of researchers reports.<br><div><br></div><div>The study, led by Guo-li Ming, M.D., Ph.D., and Hongjun Song, Ph.D., of the Johns Hopkins University School of Medicine and described online Aug. 17 in the journal Nature, used stem cells generated from people with and without mental illness to observe the effects of a rare and pernicious genetic variation on young brain cells.</div><div><br></div><div> The results add to evidence that several major mental illnesses have common roots in faulty &quot;wiring&quot; during early brain development.<br><br><blockquote class="tr_bq"><i>&quot;This was the next best thing to going back in time to see what happened while a person was in the womb to later cause mental illness. We found the most convincing evidence yet that the answer lies in the synapses that connect brain cells to one another.&quot;</i> said Ming.<br></blockquote></div></div><a href="http://www.stemcellsfreak.com/2014/08/stem-cells-show-how-illness-linked.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-29770457747244995482014-08-15T01:21:00.003-07:002014-08-15T01:21:54.125-07:00Researchers Trace the Beginnings of Hematopoietic Stem Cells<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/-unER762lTJ8/U-3CIeYTTFI/AAAAAAAACUU/D_hloeaGRyA/s1600/blood%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img alt="Red blood cell (left), a platelet (middle) and a white blood cell." border="0" src="http://1.bp.blogspot.com/-unER762lTJ8/U-3CIeYTTFI/AAAAAAAACUU/D_hloeaGRyA/s1600/blood%2Bcells.jpg" height="235" title="Blood cells " width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Blood cells<br>Red blood cell (left), a platelet (middle) <br>and a white blood cell.</td></tr></tbody></table><a href="http://www.stemcellsfreak.com/p/hematopoietic-stem-cells.html" target="_blank">Hematopoietic stem cells (HSCs)</a> differentiate to all other blood cell types, but there are still many questions about their development and how their fate is decided.<br><br>Now, in a new paper published online this week in Nature, researchers from the University of California, San Diego School of Medicine elaborate upon a crucial signaling pathway and the role of key proteins, which may help clear the way to generate HSCs from human pluripotent precursors, similar to advances with other kinds of tissue stem cells. <br><br>Principal investigator David Traver, PhD, professor in the Department of Cellular and Molecular Medicine, and colleagues focused on the Notch signaling pathway, a system found in all animals and known to be critical to the generation of HSCs in vertebrates.<br></div><a href="http://www.stemcellsfreak.com/2014/08/researchers-trace-beginnings-of.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-77830639759820334922014-08-14T00:50:00.000-07:002014-08-14T00:50:05.411-07:00Australian Researchers Unravel the Mystery of Hematopoietic Stem Cell Generation<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://4.bp.blogspot.com/-9CApnBtVYhU/U-xpajWw1iI/AAAAAAAACUE/7vOqPIPwy9I/s1600/Professor%2BPeter%2BCurrie%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img alt="Professor Peter Currie stem cells" border="0" src="http://4.bp.blogspot.com/-9CApnBtVYhU/U-xpajWw1iI/AAAAAAAACUE/7vOqPIPwy9I/s1600/Professor%2BPeter%2BCurrie%2Bstem%2Bcells.jpg" title="Professor Peter Currie"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Professor Peter Currie<br><a href="http://www.armi.org.au/about_us/staff/peter_currie.aspx" target="_blank">Credit</a></td></tr></tbody></table>A cure for a range of blood disorders and immune diseases is in sight, according to a team of scientists who have unravelled the mystery of <a href="http://www.stemcellsfreak.com/p/hematopoietic-stem-cells.html" target="_blank">hematopoietic stem cell</a> generation. The new study, led by researchers at the Australian Regenerative Medicine Institute (ARMI) at Monash University and the Garvan Institute of Medical Research, appeared yesterday in Nature. It identifies for the first time mechanisms in the body that trigger hematopoietic stem cell production.<br><br>Found in the bone marrow and in umbilical cord blood, hematopoietic stem cells (HSCs) are critically important because they can replenish the body&#39;s supply of blood cells. Leukemia patients have been successfully treated using HSC transplants, but medical experts believe blood stem cells have the potential to be used more widely.<br><br>Lead researcher Professor Peter Currie, from ARMI explained that understanding how HSCs self-renew to replenish blood cells is a &quot;Holy Grail&quot; of stem cell biology.<br></div><a href="http://www.stemcellsfreak.com/2014/08/australian-researchers-unravel-mystery.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-8982945851547975262014-08-12T13:24:00.003-07:002014-08-12T13:25:47.424-07:00Epigenetics Has Large Say in the Fate of Blood Stem Cells<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/-uolWfZ7TJbY/U-p2NpakKlI/AAAAAAAACT0/jlBZ6wgpf5A/s1600/epigenetics%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://1.bp.blogspot.com/-uolWfZ7TJbY/U-p2NpakKlI/AAAAAAAACT0/jlBZ6wgpf5A/s1600/epigenetics%2Bstem%2Bcells.jpg" height="173" width="320"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Epigenetics: Environmental effects influence<br> how genes are turned on or off.<br><b>Credit:</b> Image courtesy of Weizmann Institute of Science</td></tr></tbody></table>Every day trillions of blood cells are being formed in our body: from the oxygen-carrying red blood cells to the many types of white blood cells that fight pathogens and infection. All of these highly specialized cells originate from <a href="http://www.stemcellsfreak.com/p/hematopoietic-stem-cells.html" target="_blank">hematopoietic (blood) stem cells</a> -- unique cells that have the potential to mature into all blood types. How exactly is the fate of these stem cells regulated?<br><div><br></div><div>Preliminary findings from research conducted by scientists from the Weizmann Institute and the Hebrew University are starting to reshape the conventional understanding of the way stem cell fate decisions are controlled, thanks to a new technique for epigenetic analysis they have developed.<br></div></div><a href="http://www.stemcellsfreak.com/2014/08/epigenetics-has-large-say-in-fate-of.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-45598431027601580682014-08-12T13:09:00.001-07:002014-08-12T13:13:29.232-07:00How Breast Cancer Uses the Power of Mammary Stem Cells<div dir="ltr" style="text-align: left;" trbidi="on"><table cellpadding="0" cellspacing="0" class="tr-caption-container" style="float: left; margin-right: 1em; text-align: left;"><tbody><tr><td style="text-align: center;"><a href="http://1.bp.blogspot.com/-CImE3xKcwRQ/U-pz5Kg7YhI/AAAAAAAACTg/9Gbub9iO8mE/s1600/Dr%2BDavid%2BCheresh%2Bstem%2Bcells.jpg" imageanchor="1" style="clear: left; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img border="0" src="http://1.bp.blogspot.com/-CImE3xKcwRQ/U-pz5Kg7YhI/AAAAAAAACTg/9Gbub9iO8mE/s1600/Dr%2BDavid%2BCheresh%2Bstem%2Bcells.jpg"></a></td></tr><tr><td class="tr-caption" style="text-align: center;">Dr. David Cheresh</td></tr></tbody></table>During pregnancy, certain hormones trigger specialized mammary stem cells to create milk-producing cells essential to lactation. Researchers at the University of California, San Diego School of Medicine and Moores Cancer Center have found that mammary stem cells associated with the pregnant mammary gland are related to stem cells found in breast cancer.<br><br>Writing in the August 11, 2014 issue of Developmental Cell, David A. Cheresh, PhD, Distinguished Professor of Pathology and vice-chair for research and development, Jay Desgrosellier, PhD, assistant professor of pathology and colleagues specifically identified a key molecular pathway associated with aggressive breast cancers that is also required for mammary stem cells to promote lactation development during pregnancy.<br><br><blockquote class="tr_bq"><i>&quot;By understanding a fundamental mechanism of mammary gland development during pregnancy, we have gained a rare insight into how aggressive breast cancer might be treated. This pathway can be exploited. Certain drugs are known to disrupt this pathway and may interfere with the process of breast cancer progression.&quot;</i> said Cheresh.<br></blockquote></div><a href="http://www.stemcellsfreak.com/2014/08/how-breast-cancer-uses-power-of-mammary.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-75693068259022848312014-08-08T05:10:00.003-07:002014-08-08T05:10:35.208-07:00Dramatic Growth of Grafted Induced Pluripotent Stem Cells in Rat Spinal Cord Injuries<div dir="ltr" style="text-align: left;" trbidi="on">Building upon previous research, researchers at the University of California, San Diego School of Medicine and Veteran&#39;s Affairs San Diego Healthcare System report that neurons derived from <a href="http://www.stemcellsfreak.com/p/induced-pluripotent-stem-cells-ipscs.html" target="_blank">human induced pluripotent stem cells (iPSCs)</a> and grafted into rats after a spinal cord injury produced cells with tens of thousands of axons extending virtually the entire length of the animals&#39; central nervous system.<br><br>Leading author Paul Lu, PhD, of the UC San Diego Department of Neurosciences said the human iPSCs-derived axons extended through the white matter of the injury sites, frequently penetrating adjacent gray matter to form synapses with rat neurons. Similarly, rat motor axons pierced the human iPSCs grafts to form their own synapses.<br><br>The iPSCs used were developed from a healthy 86-year-old human male.<br><blockquote class="tr_bq"><i>&quot;These findings indicate that intrinsic neuronal mechanisms readily overcome the barriers created by a spinal cord injury to extend many axons over very long distances, and that these capabilities persist even in neurons reprogrammed from very aged human cells.&quot;</i> said senior author Mark Tuszynski, MD, PhD, professor of Neurosciences and director of the UC San Diego Center for Neural Repair.</blockquote></div><a href="http://www.stemcellsfreak.com/2014/08/dramatic-growth-of-grafted-induced.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0tag:blogger.com,1999:blog-2606396615797517651.post-91751163107162999722014-08-08T05:00:00.000-07:002014-08-08T05:01:03.218-07:00Researchers Uncover Stem Cell Behaviour of Human Bowel<div dir="ltr" style="text-align: left;" trbidi="on"><div class="separator" style="clear: both; text-align: center;"></div><div class="separator" style="clear: both; text-align: center;"><a href="http://3.bp.blogspot.com/-zwSkoVkUsQw/U-S7c-oZdQI/AAAAAAAACTE/xwRWMEWIs98/s1600/queen+mary+stem+cells.png" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" src="http://3.bp.blogspot.com/-zwSkoVkUsQw/U-S7c-oZdQI/AAAAAAAACTE/xwRWMEWIs98/s1600/queen+mary+stem+cells.png"></a></div>For the first time, researchers say they have uncovered new information on how stem cells in the human bowel behave, revealing vital clues about the earliest stages in bowel cancer development and how we may begin to prevent it.<br><br>The research, led by Queen May University of London (QMUL) and published yesterday the journal Cell Reports, discovered how many stem cells exist within the human bowel and how they behave and evolve over time.<br></div><a href="http://www.stemcellsfreak.com/2014/08/researchers-uncover-stem-cell-behaviour.html#more">Read More</a>Stem Cell Freakhttp://www.blogger.com/profile/08957660226902877521noreply@blogger.com0