Friday, 4 April 2014

Evidence indicates that VSELs from human adult tissues are multipotent

Rare, very small embryonic-like stem cells (VSELs) isolated from human adult tissues could provide a new source for developing regenerative therapies to repair complex tissues damaged by disease or trauma. The ability of these most-primitive, multipotent stem cells to differentiate into bone, neurons, connective tissue, and other cell types, and the proper criteria for identifying and isolating VSELs, are described in two new papers published in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

Russ Taichman and coauthors, University of Michigan (Ann Arbor) and NeoStem (New York, NY), implanted human VSELs into the cavity created by a cranial wound and provided the first demonstration that they could generate tissue structures containing multiple cell types.

Malwina Suszynska et al., University of Louisville, KY, and Pomeranian Medical University (Szczecin) and Jagiellonian University (Krakow), Poland, explore the challenges in isolating these rare stem cells and the importance of not confusing VSELs with other types of embryonic or reprogrammed adult pluripotent stem cells, or with monopotent adult stem cells.

“I find the data presented by the Taichman group to be compelling and challenging. However, the current debate as to the significance of the body of publications concerning VSELs can only be resolved by a cooperative investigation across laboratories using identical methodologies and source materials." said Editor-in-Chief Graham C. Parker, PhD, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.

References
http://www.liebertpub.com
- Havens A.M., Sun H., Shiozawa Y., Jung Y., Wang J., Mishra A., Jiang Y., O'Neill D.W., Krebsbach P.H. & Rodgerson D.O. & (2014). Human and Murine Very Small Embryonic-Like Cells Represent Multipotent Tissue Progenitors, In Vitro and In Vivo, Stem Cells and Development, 23 (7) 689-701. DOI:
- Suszynska M., Zuba-Surma E.K., Maj M., Mierzejewska K., Ratajczak J., Kucia M. & Ratajczak M.Z. (2014). The Proper Criteria for Identification and Sorting of Very Small Embryonic-Like Stem Cells, and Some Nomenclature Issues, Stem Cells and Development, 23 (7) 702-713. DOI:

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