As previously announced, the newly identified human adult brown fat stem cells discussed in the study have the potential to lead to the development of a cell-based method for the treatment of type 2 diabetes and obesity.
"We are very excited to have our research published in such a prestigious journal, and are thrilled to be the featured on the cover. We view the publication of research to be potential validation of our approach toward solving the growing problem of obesity and metabolic disease and we are very pleased with the prominent placement of our research." said Mark Weinreb, Chief Executive Officer of BRT.
As previously announced, BT research demonstrated that functional brown adipose derived stem cells (BADSCs) produced improvements in mice with diet-induced metabolic disorder. The results of the study showed for the first time that a multipotent stem cell population exists in human adult adipose deposits and that this population can be differentiated into metabolically functional brown adipocytes.
Brown adipocytes are key cells that are involved in energy homeostasis and metabolism. In humans, loss of brown adipose (fat) activity may account for the lower metabolism often associated with diabetes and obesity.
The study was conducted in collaboration with a team of researchers at the University of Utah School of Medicine.
- Silva FJ, Holt DJ, Vargas V, Yockman J, Boudina S, Atkinson D, Grainger DW, Revelo MP, Sherman W, Bull DA, & Patel AN (2014). Metabolically active human brown adipose tissue derived stem cells. Stem cells (Dayton, Ohio), 32 (2), 572-81 PMID: 24420906