|Mini-kidney in dish.|
The breakthrough paves the way for improved treatments for patients with kidney disease and bodes well for the future of the wider field of bioengineering organs.
Professor Melissa Little from UQ’s Institute for Molecular Bioscience (IMB), who led the study, said new treatments for kidney disease were urgently needed.
"One in three Australians is at risk of developing chronic kidney disease and the only therapies currently available are kidney transplant and dialysis. Only one in four patients will receive a donated organ, and dialysis is an ongoing and restrictive treatment regime. We need to improve outcomes for patients with this debilitating condition, which costs Australia $1.8 billion a year." Professor Little said.
The team designed a protocol that prompts stem cells to form all the required cell types to ‘self-organise’ into a mini-kidney in a dish.
"During self-organisation, different types of cells arrange themselves with respect to each other to create the complex structures that exist within an organ, in this case, the kidney. The fact that such stem cell populations can undergo self-organisation in the laboratory bodes well for the future of tissue bioengineering to replace damaged and diseased organs and tissues.I t may also act as a powerful tool to identify drug candidates that may be harmful to the kidney before these reach clinical trial." said Professor Little.
Professor Little cautioned that there was a long way to go before this might be ready for human trials, but that it was an exciting step forward.
Queensland Minister for Science and Innovation Ian Walker congratulated Professor Little and said biomedical research was crucial in ensuring a healthier future for Queenslanders.
“The work by the IMB research team is an important milestone in developing improved treatments for chronic kidney disease and will ensure those with the condition can continue to live fulfilling and productive lives,” said Mr Walker said.
The study is published in the scientific journal Nature Cell Biology and was supported by the Queensland Government, the Australian Research Council as part of the Stem Cells Australia Strategic Research Initiative, and the National Health and Medical Research Council of Australia.
- M. Takasato, P. X. Er, M. Becroft, J. M. Vanslambrouck, E. G. Stanley, A. G. Elefanty, M. H. Little (2013). Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney Nature Cell Biology DOI: 10.1038/ncb2894