Monday, 4 November 2013

Nanotechnology can advance Regenerative Medicine

A new study by Taiwanese researchers reveals how nanotechnology may be used to provide new strategies for regenerative medicine, including better tools to improve or restore damaged tissues. Published in the journal Science and Technology of Advanced Materials, the study summarizes the current state of knowledge on nanotechnology* with application to stem cell biology.

Stem cells are considered an important potential source for repairing damaged human tissues. Researchers have found that the adhesion, growth, and differentiation of stem cells are likely controlled by their surrounding microenvironment, which contains both chemical and physical cues.

These cues include the “nanotopography” of the complex extracellular matrix or architecture that forms a network for human tissues.



Summary figure. Nanotechnology regulates stem cell function.
(A) Suitable spacing for integrin activation and integrin-mediated cell adhesion,
cytoskeleton organization and cell spreading.
(B) Modified nanoscaffolds regulate stem cell self-renewal, neural differentiation
and osteogenic differentiation.
Copyright : CC-BY Yang-Kao Wang, 2013


In their paper, Yang-Kao Wang and his team describe studies showing how this nanotopography (which includes nanosized pores, grooves, ridges, etc.) plays important roles in the behaviour and fate of stem cells. 

The authors also discuss the application of nanoparticles to stem cell isolation, tracking and imaging; how to translate nanotechnology from two to three dimensions; and the potential limitations of using nanomaterials in stem cell biology.

"Understanding the interactions of nanomaterials with stem cells may provide knowledge applicable to the development of improved cell-scaffold combinations in tissue engineering and regenerative medicine.", extract from the study.


* The term “nanotechnology” refers to the design, construction, generation and use of nanoscale (1-100 nm) structures or materials.


References
1) King-Chuen Wu, Ching-Li Tseng, Chi-Chang Wu, Feng-Chen Kao, Yuan-Kun Tu, Edmund C So, Yang-Kao Wang. (2013). Nanotechnology in the regulation of stem cell behavior Science and Technology of Advanced Materials DOI: 10.1088/1468-6996/14/5/054401
2) http://www.researchsea.com

No comments:

Post a Comment

Please note that we dont offer any kind of medical advice. Questions requesting specific medical advice (e.g. where can I get this treatment, will this cure XXX condition, etc) will be published but most probably ignored by the administrators. :)

Note to spammers: You shall not pass. If you really want a link from us then consider making a stem cell related guest post !