Tuesday, 13 August 2013

Neural stem cells have the ability to hinder tumor cell growth

A new study by researchers at the 476 Hospital of Chinese PLA showed that neural stem cells transplanted into tumor-bearing rats have the ability to hinder tumor cell growth and prolife-ration. However, the mechanism remains unclear, say the researchers.

Abnormal activation of the Ras/Raf/Mek/Erk signaling cascade plays an important role in glioma. Inhibition of this aberrant activity could effectively hinder glioma cell proliferation and promote cell apoptosis.


This image shows Caspase-3 expression (arrow) in the tumor tissue of glioma model rats after neural stem cell transplantation (immunohistochemical staining, × 400).

To investigate the mechanism of glioblastoma treatment by neural stem cell trans-plantation with respect to the Ras/Raf/Mek/Erk pathway, the researchers, led by Hua Li, observed Raf-1, Erk and Bcl-2 protein expression as well as Caspase-3 protein expression. 

The researchers found that transplantation of neural stem cells could inhibit the abnormal activation of Ras/Raf/Mek/Erk signaling, thus promoting apoptosis and potentially treating glioma. The study was published in the Neural Regeneration Research.

You can download the corresponding paper by clicking here

Reference
Hua Li1, Zhenjun Chen1, Shaopeng Zhou2 (2013). Apoptosis in glioma-bearing rats after neural stem cell transplantation Neural Regeneration Research

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