Thursday, 15 August 2013

Medistem announces patent for stem cell derived nanoparticles

Medistem announced today the publication of a patent application called "Therapeutic Immune Modulation by Stem Cell Secreted Exosomes." The patent application covers the use of stem cell derived nanoparticles, termed "exosomes", for the treatment of autoimmune conditions, including Type 1 Diabetes, multiple sclerosis, rheumatoid arthritis, and lupus.


"The data presented in the patent application provides additional insight into the mechanism by which our lead product, Endometrial Regenerative Cell (ERC-124), suppresses autoimmunity in animal models of multiple sclerosis and Type 1 diabetes. Our greater understanding of the mechanism of action of ERC-124 on the immune system, will contribute to our planned FDA submission of an Investigational New Drug (IND) to treat Type 1 Diabetes with our product." said Thomas E. Ichim, Ph.D., President and Chief Scientific Officer of Medistem and co-inventor of the patent application. 

Medistem has previously published clinical proof of concept data in the in the field of autoimmunity. It has also reported four multiple sclerosis patients treated with ERC-124 in a peer-reviewed publication that is available online (see references).

"The data and intellectual property presented in the patent application supports the potential of using ERC-124 generated exosomes as an additional product candidate. Given their size, ease of storage, and unique biodistribution, we anticipate ERC-124 derived exosomes may be used to treat burn wounds, radiation sickness, and extracorporeal treatment of organs for transplantation." said Alan J. Lewis, Ph.D., Chief Executive Officer of Medistem. 

A copy of the patent application is available here

Reference
Zhong Z, Patel AN, Ichim TE, Riordan NH, Wang H, Min WP, Woods EJ, Reid M, Mansilla E, Marin GH, Drago H, Murphy MP, & Minev B (2009). Feasibility investigation of allogeneic endometrial regenerative cells. Journal of translational medicine, 7 PMID: 19232091

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