Sunday, 16 June 2013

Stem cells may help patients with avascular necrosis (AVN)

Stem cells have long been touted as the next big thing. Well just maybe, it is here. According to Dr. Dennis Lox, some patients with a disorder of the bone called avascular necrosis (AVN), have turned to stem cell therapy for aid.

 Avascular necrosis (AVN) also referred to as osteonecrosis or ischemic necrosis, is a condition in which the blood supply to the bone becomes disrupted, leading that region of bone to die. This is referred to as necrosis. The region may be very painful, and the region of necrosis may collapse resulting in severe arthritis. This has led to numerous joint replacement surgeries. It is estimated that 20,000 new cases a year of AVN, are diagnosed in the United States. AVN commonly occurs in the hip, shoulder, knee, ankle, and can even be present in multiple joints at the same time

Dr. Dennis Lox a Regenerative and Sports Medicine physician in the Tampa Bay, Florida area, comments that regenerative therapies such as Platelet Rich Plasma (PRP) and Stem Cell Therapy, are being used to treat avascular necrosis. Dr. Lox reports that what previously was a career ending injury for athletes like Bo Jackson, may not be so today if treated early. Preventing the secondary arthritis in AVN may save the joint. Also, Dr. Lox stresses, it is possible that the lost blood supply can be repaired, and stem cells have healed areas of bone necrosis.

AVN may be caused by many factors. Trauma is a frequent precipitating event. It also may be seen in some medical conditions, especially those that impair blood flow, such as embolism and thrombosis (blood clots). AVN also is seen with greater frequency with prolonged high corticosteroid usage.

Dr. Lox reports, he has treated almost every joint that gets AVN successfully with stem cells, including athletes in many different sports. He states it is imperative to get early treatment, and thoroughly evaluate each patient individually for optimal treatment decisions.

For more information Dr. Dennis Lox may be reached at (727) 462-5582 or visit

Video about avascular necrosis

1 comment:

  1. This is being done a lot of places. Dr. Thomas Einhorn in Boston, MA is the most popular destination of the moment for "AVNers" as they are known. Einhorn uses bone marrow aspirate (stem cells) and does a core decompression (a drilling technique into the necrotic--dead bone). This is based on studies in Asia that show this to a sure-fire weapon against Stages I and II avascular necrosis (especially of the hip).

    Regenexx in Denver, CO also does this although without the core decompression. Cynthia Kelly (orthopedist) in Denver, CO does a technique equivalent to Einhorn. As does the Mayo Clinic (MN).

    Alternatives are osteochondral allografts--guys in europe are doing a stem cell paste graft, equivalent to what Kevin Stone does at the Stone Clinic but for the hip. Dr. Douglass Dunlop of the spire center.

    Also, Dr. Alan Dunn of Miami, FL is doing which actually may be the sure-fire way to repair a joint. Go figure. Check it out.


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