Friday, 15 March 2013

Stem cells in the treatment of erectile dysfunction resulting from prostatectomy

A new study by a Korean research team, led by Y.S. Song, reveals that mesenchymal stem cells cultured on the surface of nanofibrous meshes may be the key for treating erectile dysfunction (ED) resulting from radical prostatectomy. The study will be presented at the 28th Annual Congress of the European Association of Urology which will be held from 15 to 19 March.

During the study, the scientists first cultivated human mesenchymal stem cells (MSCs), extracted from fat, on the surface of nanofibrous meshes, which in turn induced them into a neural-like state. Then, the researchers took 40 male Sprague-Dawley rats (2-month old) and divided them into 4 equally sized groups. All mice, except for the first group, had their cavernous nerves damaged. The main role of these cells is to facilitate penile erection and they are also the nerves damaged after radical prostatectomy, a damage which in turn causes ED.

The first group had sham operation (placebo surgery) and received no stem cells, the second had their cavernous nerves damaged and again no stem cell therapy. The third group received non-cultivated MSCs and the fourth group received the MSCs that were previously cultivated in the aforementioned nanofibrous meshes.


Male anatomy

Erectile response was assessed at 2 and 4 weeks post-op, followed by penile tissue sample harvesting.

According to the study, both the third and fourth group showed measurable improvement in their erectile function, with the fourth group having the biggest gains.

"The outcomes of the current study could be a starting point for investigating clinical application of autologous adipocyte derived mesenchymal stem cells cultivated on the nonofiber to the injured cavernous nerve after radical prostatectomy," said Song

The researchers say that it is important to conduct more clinical trials, especially in humans, to evaluate the safety and efficacy of their stem cell therapy before moving to any widespread applications.

The study is scheduled to be awarded with the 3rd prize for "best abstract in non-oncology research" in the opening day of the 28th Annual EAU Congress.


Radical prostatectomy is an operation during which the prostate gland and some of the surrounding tissue is removed. It is typically performed to remove prostate cancer. The nerves controlling the ability to have an erection lie next to the prostate gland and are commonly damaged or removed during the operation, thus many times leading to erectile dysfunction problems.

Video of a laparoscopic radical prostatectomy


Reference
Y.S. Song et al. (2013). Repair of erectile dysfunction using transplantation of human mesenchymal stem cells cultivated on the surface of nanofibrous meshes in rats with cavernous nerve injury. 28th Annual EAU Congress

2 comments:

  1. There are natural approaches to erectile dysfunction that are seriously overlooked,
    in large part because drug companies need to ensure healthy profits on their cornerstone prescription approaches, and also because
    many doctors continue to mistrust and overlook herbal approaches.
    Two of these natural remedies for erectile dysfunction
    and impotency are called Yagara and Cnidium.

    ReplyDelete
  2. Sure you keep taking your herbs and vegetables. This article discusses the use of human MSC it is an human allograft not chemicals you idiot

    ReplyDelete

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