Friday, 1 February 2013

Scientists create hiPSCs line from MODY patients

In a press release published yesterday, researchers from the Joslin Diabetes Center (JDC) announced that they have created the first line of induced pluripotent stem cells (iPSCs) derived from human patients with a rare type of diabetes, called maturity onset diabetes of the young (MODY).

The press release explains that JDC is one of the few institutes with the capacity to generate iPSCs for diabetic patients. According to the PR, the iPSCs line was created by five patients, each one presenting with a different type of MODY.

The institute's researchers will use these cells to better understand the MODY condition, by differentiating them into beta cells. Beta cells are located in the pancreas and their primary role is to store and release insulin.  They are found in the islets of Langerhans, pancreatuc regions containing endocrine.

Mouse pancreatic Langerhan islet. Beta cells can be recognised by the green insulin staining
Obtaining beta cells from living patients is impossible and lab-grown beta cells will give the researchers the ability to conduct experiments that would otherwise be impossible.

The researchers hope that that they will manage to devise ways for repairing the genetic defects of the iPSCs. This will in turn allow them to create personalised treatments for MODY patients.

Maturity onset diabetes of the young is a hereditary form of diabetes cause by genetic mutation in a single autosomal dominant gene. As of today, 8 different types of MODY have been recognised, associated with eleven different genes. If a parent has the mutated gene there is a 50 % chance that the child will inherit the condition. MODY is one of the rarest types of Diabetes, accounting for 1-2 % of all diabetic cases.

Video about the Joslin Diabetes Center

- The research was funded by the Harvard Stem Cell Institute and the National Institutes of Health

- You can read the official press release here

No comments:

Post a Comment

Please note that we dont offer any kind of medical advice. Questions requesting specific medical advice (e.g. where can I get this treatment, will this cure XXX condition, etc) will be published but most probably ignored by the administrators. :)

Note to spammers: You shall not pass. If you really want a link from us then consider making a stem cell related guest post !