Friday, 11 January 2013

New scaffold for growing mesenchymal stem cells

A collaborative team of researchers, led by Zu-yong Wang, described yesterday a new method for creating a biocompatible scaffold. The scaffold can be used for developing many different tissues including bone, muscle and cartilage from stem cells. It seems that a lot of research is going on lately on scaffolds, as it was only yesterday when we reported on a similar story.

The scaffold in question, can be used to grow human mesenchymal stem cells. The scaffold is produced by stretching a thin polymer film. According to the scientists, this stretching process creates :
"3-dimensional micro-grooves on the surface of the films"

picture of a human mesenchymal stem cell
A human mesenchymal stem cell

These microgrooves act as a support for stem cells and help them to develop into various tissues. The scaffold is resorbable, meaning that after some times it dissolves completely and only the grown tissue is left.

John Jansen, professor in Biomaterials, Experimental Implantology and Experimental Periodontology made the following statement:

"The researchers developed a very elegant method to promote cell behavior,"

- The research team was manpowered by the following institutes:
  • National UniversiTy of Singapore
  • Nanyang Technological University
  • KK Women's and Children's Hospital 
  • Duke-NUS Graduate Medical School

Biomimetic Three-Dimensional Anisotropic Geometries by Uniaxial Stretch of Poly(ɛ-Caprolactone) Films for Mesenchymal Stem Cell Proliferation, Alignment, and Myogenic Differentiation

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