Monday, 28 January 2013

Allogeneic stem cells aid in ischemic stroke recovery

In a recent animal study, scientists have shown that stem cells derived from bone marrow and fat tissue may hold the key for treating damages induced after an ischemic stroke. The findings are very interesting since all treated rats showed great recovery, achieving near-normal results in the tests that followed.

The researchers, led by María Gutiérrez-Fernández and Berta Rodríguez-Frutos, injected bone marrow and adipose-derived allogenic mesenchymal stem cells 30 minutes after an induced ischemic stroke. The scientists also used a control group that was injected with a saline solution.

According to the study, the results were simply astonishing. Just one day after the stem cell treatment all rats showed some functional improvement. Two weeks later, the treated mice had almost recovered back to their pre-stroke state. What is intriguing is that the improvement happened despite the fact that the transplanted stem cells didn't seem to migrate to the damaged brain.
No changes were noticed in the control group, strongly indicating that the recovery in the other group was the result of the stem cell treatment.

Mesenchymal stem cells

The study concludes that 14 days after the treatment, cell death was greatly decreased whereas cellular proliferation, angiogenesis , neurogenesis, oligodendrogenesis, synaptogenesis and VEGF growth factor amounts had increased.

The scientists reported similar results for both fat and bone marrow stem cells.

Gutierrez-Fernandez M, Rodriguez-Frutos B, Ramos-Cejudo J, Vallejo-Cremades MT, Fuentes B, Cerdan S, & Diez-Tejedor E (2013). Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke. Stem cell research & therapy, 4 (1) PMID: 23356495

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