Thursday, 10 January 2013

DJ-1 protein promotes mesenchymal stem cell activity and bone growth

A newly published study from a team of Korean researchers, led by Professor Pann-Gill Suh and Dr. Jung-Min Kim, shows that the DJ-1 protein promotes the growth of bone tissue. The study's findings may have potential applications in osteoporotic patients.

The researchers showed on an mice model that the DJ-1 protein stimulates the differentiation of mesenchymal stem cells into osteoblasts (bone-forming cells) by activating fibroblasts, which in turn develop into connective tissue. The study reveals that DJ-1 greatly promotes angiogenesis and osteogenesis and indicates that the protein may be a viable option for bone regeneration. One possible application of DJ-1 is for the treatment Osteoporosis.

Image of the DJ-1 Protein
DJ-1 Protein
The study was published in Nature Communications.

Osteoporosis is a condition that thins and weakens the bones, resulting in an increased risk of fracture.  It is estimated that around 10 million people are affected, in the U.S alone. The condition mainly affects elder people of all races. However white and asian females are at a higher risker.


Video about the condition


Reference
Kim JM, Shin HI, Cha SS, Lee CS, Hong BS, Lim S, Jang HJ, Kim J, Yang YR, Kim YH, Yun S, Rijal G, Lee-Kwon W, Seo JK, Gho YS, Ryu SH, Hur EM, & Suh PG (2012). DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling. Nature communications, 3 PMID: 23250426

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