|Dr. Hans-Reimer Rodewald|
In the bone marrow, hematopoietic stem cells (HSCs) give rise to a large variety of mature blood cells via progenitor cells at various stages of maturation. Now, scientists at the German Cancer Research Center (DKFZ) say have developed a way to equip mouse HSCs with a fluorescent marker that can be switched on from the outside.
Using this tool, they were able to observe, for the first time, how stem cells mature into blood cells under normal conditions in a living organism.
With these data, they developed a mathematical model of the dynamics of hematopoiesis. The researchers have now reported in the journal Nature that the normal process of blood formation differs from what scientists had previously assumed when using data from stem cell transplantations.